Rohan Janse van Rensburg, Jamba Ulengo and Uzair Cassiem will make their Springbok debuts against Wales in Cardiff while a fourth uncapped player, Jean-Luc du Preez, has been included on the bench for the final match of the November Tour.
Record try-scorer Bryan Habana is back at left wing for the Springboks when they face Italy in Florence on Saturday, while Nizaam Carr will get his first start for South Africa against the same opponents he made his Test debut against two years ago.
The Springboks have made several changes for the Test against England at Twickenham. Only five players who started in the 31-31 draw against the Barbarians last week are included in a much changed line-up for the Test.
World Rugby has unveiled the shortlists for seven top awards, including the men's and women's sevens players of the year, to be presented at the World Rugby Awards 2016 dinner in London on 13 November.
Several promising young players who have shot to prominence on the domestic scene this year, have been included in the 30-man Springbok squad for the international clash against the Barbarians on 5 November at the Wembley Stadium in London.
New Zealand equalled the record of 17 consecutive Test wins with a 57-15 victory over the Springboks at Kings Park. They also completed a perfect Rugby Championship clean sweep – six wins six bonus points.
New Zealand has won its last 16 Test matches and other than the aim of recording a clean sweep in this year’s Rugby Championship it will also be aiming to equal the record for consecutive Test wins by a Tier One Nation.
All Black selectors have brought fresh players back into the playing group which they deem vital at this time of the year as they expect to be facing a very confident South African team after their win over Australia.