The Springboks travel to Mendoza to face Los Pumas with one change to the starting lineup while Ledesma shuffles the Pumas bench.
Both the Wallabies and All Blacks announce changes for the Round 2 clash in Auckland due to injuries.
All Blacks prop Owen Franks makes his 100th appearance for the All Blacks this weekend and will be hoping to score his first try.
Is there such a thing as a talisman? Do teams struggle in the absence of key players?
The Springboks opened their Rugby Championship account with a 34-21 come-from-behind victory over Argentina at Kings Park in Durban on Saturday.
A superb all-round performance by New Zealand saw them claim a deserved 38-13 win over Australia in Saturday's Rugby Championship opener in Sydney.
David Pocock returns to the Rugby Championship this year but just how influential is the Brumby backrow forward?
All Blacks lock Sam Whitelock has ticked off a few career highlights in the last 12 months and is gearing up for his 100th cap for the All Blacks to join an exclusive club.
Super Rugby is done and dusted and now attention focuses on the Rugby Championship as the national coaches announce their extended straining squads.
Super Rugby took a break in June due to the international test window - here is a review of the action and the players who stood out ahead of The Rugby Championship later this year...
England won the Third Test in wet conditions in Cape Town but the Springboks won the series 2-1 and now look forward to The Rugby Championship.
Ireland snatched victory over the Wallabies in Sydney in a pulsating match to win the deciding Test and win the Series 2-1.
All Blacks beat France in Dunedin to wrap up comprehensive 3-0 Series win and are now focussed on defending their TRC title.
Argentina's poor June continued in Resistencia with a 15-44 loss to Scotland following recent losses to Wales.
Its down to the wire for the Wallabies against Ireland while the All Blacks and Springboks are chasing whitewash victories.
Wales without many of their established stars surprised the Pumas again to win the Second Test and the series 2-0 in Santa Fe.
The All Blacks wrapped up the Series against France with one Test to play with an unconvincing 26-13 win in Wellington.
The Wallabies have fallen to a desperate Ireland 21-26 in another tight battle at AAMI Park in Melbourne.
The Springboks overturned a 12-0 deficit to win 23-12 against England in Bloemfontein to win the June Series with one match to play.
The All Blacks, Springboks and Wallabies have all named their teams for the Second Tests of the June international series...