Argentina ended an eleven-match losing streak in the Rugby Championship when they claimed a deserved 32-19 win over South Africa in Mendoza on Saturday.
The Springboks travel to Mendoza to face Los Pumas with one change to the starting lineup while Ledesma shuffles the Pumas bench.
Is there such a thing as a talisman? Do teams struggle in the absence of key players?
The Springboks opened their Rugby Championship account with a 34-21 come-from-behind victory over Argentina at Kings Park in Durban on Saturday.
Super Rugby is done and dusted and now attention focuses on the Rugby Championship as the national coaches announce their extended straining squads.
Super Rugby took a break in June due to the international test window - here is a review of the action and the players who stood out ahead of The Rugby Championship later this year...
England won the Third Test in wet conditions in Cape Town but the Springboks won the series 2-1 and now look forward to The Rugby Championship.
Its down to the wire for the Wallabies against Ireland while the All Blacks and Springboks are chasing whitewash victories.
The Springboks overturned a 12-0 deficit to win 23-12 against England in Bloemfontein to win the June Series with one match to play.
The All Blacks, Springboks and Wallabies have all named their teams for the Second Tests of the June international series...
Springboks come from 21 points behind to overhaul England and then hang on to win a sensational match 42-39 at Emirates Airline Park, Johannesburg.
S’busiso Nkosi, Aphiwe Dyantyi and RG Snyman will make their Springbok debuts when South Africa face England in the First Test in Johannesburg.
Wallabies coach Michael Cheika has confirmed his squad for the blockbuster three-Test Ireland Series that kicks off at Suncorp Stadium on Saturday 9 June.
New Zealand overturned a half-time deficit to claim a 14-10 victory over South Africa in a thrilling Rugby Championship Test at Westpac Stadium on Saturday.